arcarg3.1 interacts with the endocytic machinery to

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Arc/Arg3.1 interacts with the endocytic machinery to ...

Arc/Arg3.1 is an immediate-early gene whose mRNA is rapidly transcribed and targeted to dendrites of neurons as they engage in information processing and storage. Moreover, Arc/Arg3.1 is known to be required for durable forms of synaptic plasticity and learning. Despite these intriguing links to pla

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Arc/Arg3.1 Interacts with the Endocytic Machinery to ...

2006-11-9  Strikingly, Arc/Arg3.1 only interacts with endophilins 2 and 3, but not 1, suggesting that isoform specificity can indeed confer particular properties to specific endocytic pathways. Specific endocytic zones, segregated from the postsynaptic density (PSD), can be found in the lateral margins of excitatory synapses (Blanpied et al., 2002).

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Arc/Arg3.1 Interacts with the Endocytic Machinery to ...

Arc/Arg3.1 is an immediate-early gene whose mRNA is rapidly transcribed and targeted to dendrites of neurons as they engage in information processing and storage. Moreover, Arc/Arg3.1 is known to be required for durable forms of synaptic plasticity and learning. Despite these intriguing links to plasticity, Arc/Arg3.1's molecular function remains enigmatic. Here, we demonstrate that Arc/Arg3.1 ...

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(PDF) Arc/Arg3.1 Interacts with the Endocytic Machinery to ...

Arc/Arg3.1 Is Recruited with Endophilin and Dynamin to Vesicles in HeLa Cells (A) Arc/Arg3.1 expressed alone has a cytoplasmic and nuclear distribution in HeLa cells,

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52 Arc/Arg3.1 Interacts with the Endocytic Machinery to ...

2012-10-7  Arc/Arg3.1 Interacts with the Endocytic Machinery to Regulate AMPA Receptor Trafficking Shoaib Chowdhury, 1 ,7Jason D. Shepherd, 2 3 Hiroyuki Okuno, 1,8 Gregory Lyford, Ronald S. Petralia,5 Niels Plath,6 Dietmar Kuhl,6 Richard L. Huganir, 1 ,23 and Paul F. Worley 4 * 1Department of Neuroscience 2Cellular and Molecular Medicine Graduate Program

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Arc/Arg3.1 interacts with the endocytic machinery to ...

2006-11-1  Arc Interacts with the Endocytic Machinery to Regulate AMPA Receptor Trafficking Shoaib Chowdhury , 1, 8 Jason D. Shepherd , 1, 2, 3, 8 Hiroyuki Okuno , 1, 7 Gregory Lyford , 1 Ronald S. Petralia , 5 Niels Plath , 6 Dietmar Kuhl , 6 Richard L. Huganir , 1, 2, 3 and Paul F. Worley 1, 2, 4

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Arc/Arg3.1 interacts with the endocytic machinery to ...

2006-11-1  Moreover, Arc/Arg3.1 is known to be required for durable forms of synaptic plasticity and learning. Despite these intriguing links to plasticity, Arc/Arg3.1's molecular function remains enigmatic. Here, we demonstrate that Arc/Arg3.1 protein interacts with dynamin and specific isoforms of endophilin to enhance receptor endocytosis.

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(PDF) Arc/Arg3.1 Interacts with the Endocytic Machinery to ...

Arc/Arg3.1 Interacts with the Endocytic Machinery to Regulate AMPA Receptor Trafficking. Jason Shepherd. Neuron 52, 445–459, November 9, 2006 ª2006 Elsevier Inc. DOI 10.1016/j.neuron.2006.08.033 Arc/Arg3.1 Interacts with the Endocytic Machinery to Regulate AMPA Receptor Trafficking Shoaib Chowdhury,1,7 Jason D. Shepherd,1,2,3,7 revealed a ...

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Essential role of the endocytic site-associated protein ...

How cells adopt a different morphology to cope with stress is not well understood. Here, we show that budding yeast Ecm25 associates with polarized endocytic sites and interacts with the polarity regulator Cdc42 and several late-stage endocytic proteins via distinct regions, including an actin filam

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Endocytic Machinery Protein SlaB Is Dispensable for ...

2020-12-18  The Aspergillus nidulans endocytic internalization protein SlaB is essential, in agreement with the key role in apical extension attributed to endocytosis. We constructed, by gene replacement, a nitrate-inducible, ammonium-repressible slaB1 allele for conditional SlaB expression. Video microscopy showed that repressed slaB1 cells are able to establish but unable to maintain a stable polarity ...

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Endocytic Machinery Protein SlaB Is Dispensable for ...

2020-12-18  The Aspergillus nidulans endocytic internalization protein SlaB is essential, in agreement with the key role in apical extension attributed to endocytosis. We constructed, by gene replacement, a nitrate-inducible, ammonium-repressible slaB1 allele for conditional SlaB expression. Video microscopy showed that repressed slaB1 cells are able to establish but unable to maintain a stable polarity ...

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Coupled sterol synthesis and transport machineries at ER ...

2021-7-20  We previously showed that the yeast sterol transporter Osh2 is recruited to endoplasmic reticulum (ER)–endocytic contacts to facilitate actin polymerization. We now find that a subset of sterol biosynthetic enzymes also localizes at these contacts and interacts with Osh2 and the endocytic machinery.

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Brain‐specific functions of the endocytic machinery

endocytic machinery in the brain, focusing on three main types of brain cells: neuronal progenitor cells, neurons, and glial cells. We note that this review high-lights endocytic pathways occurring at the PM (and/or noncanonical functions of ‘classical’ endocytosis

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Machinery, regulation and pathophysiological implications ...

2021-7-23  ARL8 directly interacts with kinesin 3, or interacts with its effector SKIP, which in turn couples to kinesin 1 (ref. 48). Depletion of BORC complex decreases the fusion of peripheral ...

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The endocytic machinery in nerve terminals surrounds

1999-12-2  In most models of endocytosis, the endocytic machinery is recruited from the cytoplasm by cytoplasmic tails of the plasma membrane proteins that are to be internalized. This does not appear to be true at synapses where the endocytic machinery required for synaptic vesicle recycling is localized to membrane-associated ‘hot spots’ [1] , [2] .

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ubiquitin code and its decoding machinery in the

2013-4-5  The plasma membrane, a lipid bilayer that separates the cytoplasm from the extracellular space, is the site where extracellular signals (e.g. hormones and growth factors) are received by the cell, changes in environmental conditions are sensed, molecules and ions are transported between the inside and outside of the cell, and interaction with neighbouring cells and extracellular matrices occurs.

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AMSH interacts with ESCRT-0 to regulate the stability and ...

2010-4-30  AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4. Sierra MI (1), Wright MH, Nash PD. (1)Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA. Reversible ubiquitination is essential for the endocytic sorting and down-regulation of G protein-coupled receptors, such as the ...

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Gαs regulates the post-endocytic sorting of G protein ...

2014-8-4  The role of Gαs in G protein-coupled receptor (GPCR) signalling at the cell surface is well established. Recent evidence has revealed the presence of

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Rabankyrin-5 Interacts with EHD1 and Vps26 to Regulate ...

Rabankyrin-5 Interacts with EHD1 and Vps26 to Regulate Endocytic Trafficking and Retromer Function Jing Zhang, Calliste Reiling, James B. Reinecke, Iztok Prislan, Luis A. Marky , Paul L. Sorgen , Naava Naslavsky , Steve Caplan

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HIV-1 Nef interacts with the cyclin K/CDK13 complex to ...

2021-8-30  HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity.Cell Rep.2021 Aug 10;36(6):109514.doi: 10.1016/j.celrep.2021.109514

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Endocytic Machinery Protein SlaB Is Dispensable for ...

2020-12-18  The Aspergillus nidulans endocytic internalization protein SlaB is essential, in agreement with the key role in apical extension attributed to endocytosis. We constructed, by gene replacement, a nitrate-inducible, ammonium-repressible slaB1 allele for conditional SlaB expression. Video microscopy showed that repressed slaB1 cells are able to establish but unable to maintain a stable polarity ...

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The protein architecture of the endocytic coat analyzed by ...

2020-5-13  The endocytic machinery consists of dozens of proteins, which assemble beneath the plasma membrane, at the endocytic site, to mediate the endocytic site initiation, cargo selection, membrane invagination, and finally vesicle scission and uncoating (Kaksonen Roux, 2018).

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The endocytic machinery in nerve terminals surrounds

1999-12-2  In most models of endocytosis, the endocytic machinery is recruited from the cytoplasm by cytoplasmic tails of the plasma membrane proteins that are to be internalized. This does not appear to be true at synapses where the endocytic machinery required for synaptic vesicle recycling is localized to membrane-associated ‘hot spots’ [1] , [2] .

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The Endocytic Pathway and the Actin Cytoskeleton IBMB

Projects: 1. Function and regulation of ER-endocytic contact sites and the mechanism of sterol-induced actin polymerization. We previously demonstrated that the endoplasmic reticulum (ER) contacts the endocytic sites to facilitate actin polymerization and membrane invagination during endocytic uptake.

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Endocytosis Is Crucial for Cell Polarity and Apical ...

2020-12-18  Establishing the occurrence of endocytosis in filamentous fungi was elusive in the past mainly due to the lack of reliable indicators of endocytosis. Recently, however, it was shown that the fluorescent dye N-(3-triethylammoniumpropyl)-4-(p-diethyl-aminophenyl-hexatrienyl)pyridinium dibromide (FM4-64) and the plasma membrane protein AoUapC (Aspergillus oryzae UapC) fused to enhanced

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ubiquitin code and its decoding machinery in the

2013-4-5  The plasma membrane, a lipid bilayer that separates the cytoplasm from the extracellular space, is the site where extracellular signals (e.g. hormones and growth factors) are received by the cell, changes in environmental conditions are sensed, molecules and ions are transported between the inside and outside of the cell, and interaction with neighbouring cells and extracellular matrices occurs.

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Beclin-1-interacting autophagy protein Atg14L targets the ...

Autophagy is hence highly intertwined with the endocytic trafficking pathway, sharing similar molecular machinery. Atg14L, also known as Beclin 1-associated autophagy-related key regulator (Barkor), directly interacts with Beclin 1 through its coiled-coil domain and enhances phosphatidylinositol 3-phosphate kinase class III (PI3KC3) activity to ...

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Rabankyrin-5 Interacts with EHD1 and Vps26 to Regulate ...

Rabankyrin-5 Interacts with EHD1 and Vps26 to Regulate Endocytic Trafficking and Retromer Function Jing Zhang, Calliste Reiling, James B. Reinecke, Iztok Prislan, Luis A. Marky , Paul L. Sorgen , Naava Naslavsky , Steve Caplan

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Regulation of Endocytic Sorting by ESCRT–DUB-Mediated ...

2011-3-30  Homeostatic regulation of receptor abundance at the plasma membrane is largely accomplished though endocytosis, and malfunctions along this pathway are associated with a plethora of pathologies, including cancer [1, 2].Following their uptake into endocytic vesicles, cell surface receptors are sorted either to the lysosome for degradation or recycled back to the plasma membrane.

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Rabankyrin‐5 Interacts with EHD1 and Vps26 to Regulate ...

2012-1-27  Rabankyrin‐5 Interacts with EHD1 and Vps26 to Regulate Endocytic Trafficking and Retromer Function Jing Zhang Department of Biochemistry and Molecular Biology and Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198‐5870 USA

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